Best Pain Medicine

As the name suggests, this medicine is an instant, powerful cure for splitting headaches. It’s also highly effective for migraines. The product includes 100 tablets with Acetaminophen 250mg, Aspirin 250mg (NSAID), and Caffeine 65mg as the active ingredients.

How does it work? Our Extra Strength Headache Relief combines the power of two common painkillers (Acetaminophen and Aspirin) and amplifies their effects using caffeine. First and foremost, Acetaminophen reduces fever by helping the body expend excessive heat and increases its pain threshold. Meanwhile, the Aspirin minimizes the formation of prostaglandins, which helps eliminate any inflammation/swelling and pain. Finally, the caffeine does its magic with vasoconstriction, a phenomenon in which the body's blood vessels constrict, reducing the flow of blood, and eliminating any symptoms of headache or migraine.

What should I know about it? You should avoid taking this medicine with any other medication that includes Acetaminophen. An overdose of Acetaminophen can lead to liver damage. Furthermore, if you have a history of getting an upset stomach after taking Aspirin (a common side-effect), take the medicine with food and avoid heavy drinking as it can result in stomach bleeding. Finally, make sure to keep your caffeine intake under control (a single dose includes the same amount of caffeine found in a cup of coffee).

Compares to: Excedrin® Extra Strength 

Best for: Individuals looking for quick and powerful relief against headaches and are not on any other medication that includes Acetaminophen. 

Do you need medicine that provides gentle relief against minor aches and other forms of acute pain and helps you fall asleep? Our Pain Reliever & Nighttime Sleep Aid fits that description. Each bottle includes 100 tablets, each made up of Acetaminophen 500mg and Diphenhydramine HCl 25mg.

How does it work? The Acetaminophen in this medicine plays the role of the painkiller. It works by increasing your body's overall pain threshold. Furthermore, it helps reduce fever by eliminating excessive body heat. Meanwhile, Diphenhydramine acts as a sleep aid by preventing Histamine from acting, inducing drowsiness.

What should I know about it? You should take this medicine at bedtime. If you’re on any other medication that includes Acetaminophen, avoid taking this medicine as you might go over the recommended maximum dosage of Acetaminophen (which is 4,000mg) and damage your liver. Finally, make sure you don’t take this medicine with alcohol.

Compares to: Tylenol® PM

Best for: Individuals who want a caffeine-free pain treatment at night. 

This pain medicine is a classic OTC, non-prescription drug that reduces fever and alleviates pain, with Acetaminophen 500mg as the only active ingredient. It’s comparable to Extra Strength Tylenol® and other brand names with the same composition and uses.

How does it work? As highlighted above, Acetaminophen works by increasing your body’s pain threshold (different from Opiates like Codeine, Oxycodone/Oxycontin, and hydrocodone used in Vicodin) and reducing fever by helping it release excess heat. It doesn't target the exact area/root cause of the pain. Instead, it changes your body's perception of pain.

What should I know about it? Don’t take this medicine if you’re on any other medication that also uses Acetaminophen as one of the active ingredients.

Compares to: Tylenol®  

Best for: People who want fast and effective relief from fever and/or different types of pain, like headaches, back pain, muscle sprains, arthritis, and menstrual cramps. 

Ibuprofen is a nonsteroidal anti-inflammatory drug that provides fast relief from different kinds of pain, including headaches, menstrual cramps, arthritis, and muscle sprain. It can also reduce fever. Each bottle of this pain medicine contains 100 tablets with Ibuprofen 100mg (NSAID) as the main active ingredient.

How does it work? Ibuprofen relieves pain by blocking the production of prostaglandins, which are compounds that your body releases when you’re ill or injured. It’s similar to Aspirin in that sense.

What should I know about it? If you’ve ever suffered from an upset stomach after taking Ibuprofen, try taking it with food or after having a meal. Furthermore, avoid taking this medicine with alcohol, since it could damage your kidneys. 

Compares to: Advil® (and also Motrin®)

Best for: Individuals looking for instant relief from mild or severe pain and don’t have any heart diseases, kidney-related problems, and other complications. 

Aspirin is the most widely-known over-the-counter pain control medicine. This version of the pain medicine includes 325mg of Aspirin and can help relieve headaches and minor arthritis pain.

How does it work? Aspirin works in the same way as Ibuprofen when it comes to alleviating pain. It works by blocking the production of prostaglandins that regulate pain.

What should I know about it? Aspirin could upset your stomach if taken without food. However, this pain medicine is coated with Enteric, which can help it dissolve safely without irritating your stomach.

Compares to: Ecotrin® Tablets

Best for: Individuals who want a strong solution for inflammation and pain. 

This medicine is the same as the previous one, but includes a smaller dosage of Aspirin (81mg), and is therefore perfect for daily aspirin therapy (without any serious side effects).

Compares to: Bayer® Low Dose Aspirin Regimen

Best for: People who have been prescribed daily aspirin therapy by their health care provider.